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Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium salt and chloride in approximately equivalent amounts.In normal volunteers, a dose of telmisartan 80 mg inhibited the pressor response to an intravenous infusion of angiotensin II by about 90% at peak plasma concentrations, with approximately 40% inhibition persisting for 24 hours. Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity (PRA) and angiotensin II circulating levels do not overcome the effect of telmisartan on blood pressure. These side effects are minor and usually disappear within a week or two.The major side effects include dizziness, nausea, swelling of the hands, ankles, or feet and sudden weight gain. Telmisartan has much greater affinity (more than 3000-fold) for the AT1 receptor than for the AT2 receptor. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases PRA, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.The common side effects of Cresar H: diarrhea, headache, vomiting, nausea, chest congestion, fatigue, body and muscle aches. The mechanism of the antihypertensive effect of thiazides is not fully understood.Telmisartan does not inhibit the angiotensin converting enzyme ; hence, it does not affect the response to bradykinin. Its action is, therefore, independent of the pathways for angiotensin II synthesis. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics. Cresar H is a fixed-dose combination of Telmisartan, an orally active angiotensin II antagonist acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic. This combination provides synergistic reduction in blood pressure in hypertension patients. If you have an allergy to this medicine, you will experience symptoms such as swelling of the tongue, throat or face, rashes, itchiness and difficulty breathing.Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. If they continue for a prolonged period, consult your doctor.After oral administration of Cresar H, diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours.
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